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KMID : 0043320140370070852
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Archives of Pharmacal Research
2014 Volume.37 No. 7 p.852 ~ p.861
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Novel arylhydrazone derivatives bearing a rhodanine moiety: synthesis and evaluation of their antibacterial activities
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Li Wei
Zheng Chang Ji
Sun Liang Peng
Song Ming Xia
Wu Yan
Li Yin Jing
Liu Yi
Piao Hu Ri
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Abstract
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A series of arylhydrazone derivatives bearing a rhodanine moiety have been synthesized, characterized, and evaluated as antibacterial agents. Some of these compounds showed potent antibacterial activities against several different strains of Gram-positive bacteria, including multidrug-resistant clinical isolates. Of the compounds tested, IIk and IIIk were identified as the most effective, with minimum inhibitory concentration values of 2?4 μg/mL against multidrug-resistant Gram-positive organisms, including methicillin-resistant and quinolone-resistant Staphylococcus aureus. None of the compounds exhibited any activity against the Gram-negative bacteria Escherichia coli 1356 at 64 μg/mL.
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KEYWORD
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Arylhydrazone, Rhodanine, Antibacterial activity, Methicillin-resistant Staphylococcus aureus, Quinolone-resistant Staphylococcus aureus
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